Fatostatin hydrobromide
Fatostatin A Hydrobromide
CAS: 298197-04-3
Molecular Formula: C18H19BrN2S
Fatostatin hydrobromide - Names and Identifiers
Fatostatin hydrobromide - Physico-chemical Properties
| Molecular Formula | C18H19BrN2S |
| Molar Mass | 375.33 |
| Solubility | DMSO: ≥10mg/mL |
| Appearance | powder |
| Color | light yellow to yellow |
| Storage Condition | 2-8°C |
| In vitro study | Fatostatin inhibits insulin-induced lipogenesis in 3T3-L1 cells and serum-independent growth of DU145 cells. Fatostatin inhibits activation of SREBPs in cells in tissue culture. Fatostatin inhibits cell proliferation, attachment-independent colony formation, and their in vitro invasion and metastasis in androgen-responsive LNCaP cells and androgen-insensitive C4-2B prostate cancer cells. In addition, fatostatin causes G2/M cell cycle arrest, induces apoptosis by increasing caspase-3/7 activity and caspase-3, PARP division. |
| In vivo study | Fatostatin prevented the increase in body weight, blood glucose and liver fat accumulation in obese ob/ob mice, even though food intake was not controlled. Fatostatin significantly inhibited the growth of subcutaneous C4-2B tumors and reduced serum PSA levels. |
Fatostatin hydrobromide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 1 |
Fatostatin hydrobromide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.664 ml | 13.322 ml | 26.643 ml |
| 5 mM | 0.533 ml | 2.664 ml | 5.329 ml |
| 10 mM | 0.266 ml | 1.332 ml | 2.664 ml |
| 5 mM | 0.053 ml | 0.266 ml | 0.533 ml |
Last Update：2024-01-02 23:10:35
Fatostatin hydrobromide - Reference Information
| biological activity | Fatostatin HBr (Fatostatin A, 125B11) is an inhibitor of sterol regulatory element binding protein (drebp). It impairs SREBP-1 and SREBP-2 activation. |
| Target | Value |
Last Update：2024-04-09 21:32:10
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Spot supply
Product Name: Fatostatin A Hydrobromide Visit Supplier Webpage Request for quotationCAS: 298197-04-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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